Following the devastating wildfires from August 8-11, 2023, the Maui community has faced significant challenges including environmental hazards, air pollution, and toxic substances that pose additional long-term health risks. In response, we launched the Maui Wildfire Exposure Cohort Study (MauiWES). Our initial findings highlight the critical health needs to address acute conditions, including depression, hypertension, respiratory issues, and other risk factors that portend long-term chronic disease progression.